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A newer car from the current generation if your budget allows it — Lexus has repeatedly reworked the LS's cabin technology and ride comfort generation over generation, and the newest available example will have the most resolved version of both.
The Mercedes E300 is far cheaper if you don't need full-size flagship space. The BMW 735 sits at a similar price and is the direct German cross-shop. Inside the Lexus range, the LS500h is the hybrid version of the same flagship.
Well past 100,000 km on the cars we see, with a median of around 100,000 km on the examples currently in our stock and no notable mechanical pattern — a flagship saloon like this is usually driven gently and maintained through the dealer network.
Read the CarSwitch inspection report before you buy — on a car this complex, it is worth more than a test drive alone.